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Therefore, the use of other agents in combination with zidovudine to No pharmacologic interactions between acyclovir and zidovudine or

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Acyclovir is phosphorylated by a viral kinase, but AZT is phosphorylated to the This lead to combination therapy, the use of two antiviral drugs to combat

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No unusual toxicities could be attributed to the zidovudine and high-dose acyclovir combination during the 12-week observation period. Full text. Full text is

that acyclovir (§3200 mg/day) offered a significant survival benefit (P Å .006 by log-rank zidovudine alone and in combination with acyclovir for treatment of

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AZT may be used in combination with other antiretroviral medications to anti- HIV agents; however, acyclovir and ribavirin decrease the antiviral effect of AZT.

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The combinations of zidovudine plus recombinant [beta]-interferon, castanospermine or acyclovir have been found to possess synergistic activity against HIV in

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AZT (Retrovir®, zidovudine, ZDV): The first drug licensed to treat HIV. Today it is almost always used in combination with other anti-HIV drugs. Side effects

AZT is combined with other drugs in order to prevent mutation of HIV into an or synergistically with many antiviral agents such as acyclovir and interferon;

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AZT was also FDA approved (08/08/94) to prevent HIV transmission

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Keywords: DRUGS TOLERANCE, NUCLEOSIDES ANALOGS, ACYCLOVIR, THERAPY Abstract: The objects of this study are to determine if AZT prolongs the . in part to the use of combination, highly active, antiretroviral therapy ( HAART),

become an important class of agents for both viral (examples: Acyclovir, AZT and AZT (also known as Zidovudine) is used in combination with other anti-virus


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