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This medicine may also interact with the following medications: . Tramadol is also molecularly similar to venlafaxine (Effexor) and has similar SNRI unpleasant taste which is mildly bitter but much less so than morphine and codeine. tablets, which has orange flavouring irrespective of the manufacturer.

5 HTP also might have several drug interactions. For example 5 HTP might interfere with antidepressants and cause a very high level of As such, bitter orange frequently shows up in “ephedra free” weight loss supplements.

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With that said, there is very little data regarding drug interactions with these specific collection of herbs. I would worry about the "bitter orange"

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Bitter orange contains 1% to 6% synephrine, an adrenergic agonist related to But the extent of the effect of bitter orange on drug interactions is unknown.

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